Outline
A new concept of life sciences has been revealed by sulfur-based redox biology. Living systems use redox potential-based energy metabolism to produce ATP. Redox research has been developed by investigating pathophysiological roles of specific signaling pathways induced by chemical modification of intracellular molecules with oxygen-derived byproducts of energy metabolism, including reactive oxygen species (ROS) and electrophiles. Recently, reactive sulfide species, represented by persulfide and polysulfide, have been revealed to function as endogenous nucleophile that can react with, metabolize, and eliminate electrophiles. These reactive sulfides are also found to participate in physiological energy metabolism coupling with electron transfer and formation of iron-sulfur clusters. This symposium will introduce cutting-edge researches on the molecular bases of sulfur-based redox signaling and their new biological roles in mammalian systems.