Schedule
Program
- Plenary Lectures
- Meet the Expert
- Symposia
- Forum
- Talks (Oral Presentation from Poster) & Posters
- Late-breaking Abstracts
- Samuro Kakiuchi Memorial Award winning lectures
- The Young Investigator Award lecture of the JBS winning lectures
- The JB Prize Winning Papers
- Journal of Biochemistry Luncheon Workshop
- Workshop on Gender Equality
- Bio-industry Seminar (Luncheon Seminar)
Plenary Lectures
1PL01
Insights into the Future from Analysis of the Past Genetic Research and its Impact on the future of Personalized Medicine
James Douglas Engel (University of Michigan, USA)
Date: September 25 10:30-11:30
Place: Room 1 (Main Hall, Sendai International Center)
Chair: Satoru Takahashi (Univ. of Tsukuba)
3PL01
Targeting the Nrf2 Signaling Pathway for Cancer Prevention
Thomas Kensler (University of Pittsburgh, USA)
Date: September 27 12:45-13:45
Place: Room 1 (Main Hall, Sendai International Center)
Chair: Ken Itoh (Hirosaki Univ.)
Meet the Expert *in Japanese
We invite distinguished researchers as speakers of this program. It is a valuable opportunity that speakers talk about their researches a little frankly and closer to the audience than regular lectures.
September 26 8:00-8:45
Recent progress in phospholipid research
Takao Shimizu (National Center for Global Health and Medicine/ The University of Tokyo)
Chair: Hozumi Motohashi (Tohoku Univ.)
PGRMC1: A novel CO-responsive regulator of cancer
Makoto Suematsu (Keio University)
Chair: Ritsuko Shimizu (Tohoku Univ.)
Novel functions of nuclear transport factors
Yoshihiro Yoneda (National Institutes of Biomedical Innovation, Health and Nutrition)
Chair: Hironobu Ikehata (Tohoku Univ.)
September 27 08:0-8:45
My Proteasome Study
Keiji Tanaka (Tokyo Metropolitan Institute of Medical Science)
Chair: Akiyoshi Fukamizu (Univ. of Tsukuba)
Discovery of drug target molecules based on natural products chemical biology
Minoru Yoshida (RIKEN)
Chair: Takashi Moriguchi (Tohoku Univ.)
Lesson from my research for last 60 years
Susumu Nishimura (Laboratory Animal Resource Center, University of Tsukuba)
Chair: Norio Suzuki (Tohoku Univ.)
Symposia
List of Symposia
| No. | Date | Place | Session Theme |
|---|---|---|---|
| 1S01 | September 25 | Room 1 (Main Hall, Conference bldg., Sendai International Center) | Dysregulation of Oxygen Remodeling and Disease Pathogenesis |
| 1S02 | September 25 | Room 2 (Tachibana, Conference bldg., Sendai International Center) | New Horizon of Biochemistry using genome editing technology |
| 1S03 | September 25 | Room 3 (Hagi, Conference bldg., Sendai International Center) | Chemical biology on the biologiccally active compounds |
| 1S04 | September 25 | Room 4 (Sakura 1, Conference bldg., Sendai International Center) | Academia drug discovery |
| 1S05 | September 25 | Room 5 (Sakura 2, Conference bldg., Sendai International Center) | Multi-omics: new insights into disease biology |
| 1S06 | September 25 | Room 6 (Shirakashi 1, Conference bldg., Sendai International Center) | New aspects of the mechanisms underlying diverse cell death and its pathophysiological significances |
| 1S07 | September 25 | Room 7 (Shirakashi 2, Conference bldg., Sendai International Center) | Failure of protein structure and the disease: from physical chemistry to clinical medicine |
| 1S08 | September 25 | Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center) | Adult Stem Cells, Tissue Regeneration and Disease Mechanism |
| 1S09 | September 25 | Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center) | Recent advances of sirtuin research: From the molecular bases to its roles in diseases |
| 1S10 | September 25 | Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center) | Intersection of oncology and immunology: Recent progress in the phosphorylation research and its therapeutic application |
| 1S11 | September 25 | Room 11 (B200, Lecture Rooms B, Kawauchi Campus) | The origin of Organellostasis |
| 1S12 | September 25 | Room 12 (B201, Lecture Rooms B, Kawauchi Campus) | Protein complex and protein network from the point of view of motifs |
| 1S13 | September 25 | Room 13 (B202, Lecture Rooms B, Kawauchi Campus) | High resolution electron microscopy targeted on protein complex analysis |
| 1S14 | September 25 | Room 14 (B203, Lecture Rooms B, Kawauchi Campus) | Membrane dynamics-mediated regulation of cellular interactions with extracellular environments |
| 1S15 | September 25 | Room 15 (B204, Lecture Rooms B, Kawauchi Campus) | Nuclear and chromatin dynamics in human diseases |
| 1S16 | September 25 | Room 16 (B101, Lecture Rooms B, Kawauchi Campus) | Diversity of Stem /Progenitor Cells for Cardiovascular System and its Implication to Human Diseases |
| 1S17 | September 25 | Room 17 (B102, Lecture Rooms B, Kawauchi Campus) | Eyewitness real-time platelet-fibrin thrombus formation and its lysis at single molecular and cellular levels! |
| 1S18 | September 25 | Room 18 (B103, Lecture Rooms B, Kawauchi Campus) | Heating Up: The Emergence of Thermal Biology |
| 1S19 | September 25 | Room 19 (B104, Lecture Rooms B, Kawauchi Campus) | Central role of ribosome in gene regulation |
| 2S01 | September 26 | Room 1 (Main Hall, Conference bldg., Sendai International Center) | Integration mechanisms of extracellular environments into transcription and epigenomes |
| 2S02 | September 26 | Room 2 (Tachibana, Conference bldg., Sendai International Center) | Diabetes as disturbed states of systemic glucose metabolism |
| 2S03 | September 26 | Room 3 (Hagi, Conference bldg., Sendai International Center) | Genome analyses and biochemistry |
| 2S05 | September 26 | Room 5 (Sakura 2, Conference bldg., Sendai International Center) | Biology of chronic inflammation |
| 2S06 | September 26 | Room 6 (Shirakashi 1, Conference bldg., Sendai International Center) | Redox signals regulating organelle environment |
| 2S07 | September 26 | Room 7 (Shirakashi 2, Conference bldg., Sendai International Center) | Advanced research of unique toxin/venom-related animals based on Venomics project |
| 2S08 | September 26 | Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center) | Hematopoiesis and Environment |
| 2S09 | September 26 | Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center) | Hypoxia and Disease |
| 2S10 | September 26 | Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center) | Proteostasis and age-related diseases |
| 2S11 | September 26 | Room 11 (B200, Lecture Rooms B, Kawauchi Campus) | Organelle homeostasis; Organelle stress response and crosstalk between organelles |
| 2S12 | September 26 | Room 12 (B201, Lecture Rooms B, Kawauchi Campus) | Dynamics of protein complex for cellular robustness |
| 2S13 | September 26 | Room 13 (B202, Lecture Rooms B, Kawauchi Campus) | Emerging roles of Arf and Arl family (G protein) in development, neurological functions, tumorigenesis, and metastasis. |
| 2S14 | September 26 | Room 14 (B203, Lecture Rooms B, Kawauchi Campus) | Innovative Bio-science into molecular mechanism of membrane proteins |
| 2S15 | September 26 | Room 15 (B204, Lecture Rooms B, Kawauchi Campus) | Protein-Nucleic Acid Interaction Regulating the Genome Maintenance and Inheritance |
| 2S16 | September 26 | Room 16 (B101, Lecture Rooms B, Kawauchi Campus) | Roles of vascular systems in the maintenance of homeostasis |
| 2S17 | September 26 | Room 17 (B102, Lecture Rooms B, Kawauchi Campus) | New aspects of signaling molecules in bacterial two-component regulatory systems that elicit adaptive responses to environments |
| 2S18 | September 26 | Room 18 (B103, Lecture Rooms B, Kawauchi Campus) | Cutting edge of imaging technologies for neurobiology research |
| 2S19 | September 26 | Room 19 (B104, Lecture Rooms B, Kawauchi Campus) | Potential of antibodies at new frontiers: Hot topics for liberating the potential of antibodies |
| 3S01 | September 27 | Room 1 (Main Hall, Conference bldg., Sendai International Center) | Autophagy machinery and function |
| 3S02 | September 27 | Room 2 (Tachibana, Conference bldg., Sendai International Center) | Disorder of iron metabolism：disease and pathophysiology |
| 3S03 | September 27 | Room 3 (Hagi, Conference bldg., Sendai International Center) | Molecular basis for age-associated stem cell changes and diseases |
| 3S04 | September 27 | Room 4 (Sakura 1, Conference bldg., Sendai International Center) | Exploring new oxygen biology with cutting-edge imaging technologies |
| 3S05 | September 27 | Room 5 (Sakura 2, Conference bldg., Sendai International Center) | Development of molecularly targeted cancer drugs by fusion of different fields |
| 3S06 | September 27 | Room 6 (Shirakashi 1, Conference bldg., Sendai International Center) | Making the most out of structures -Critical role of structural information in modern life science research- |
| 3S07 | September 27 | Room 7 (Shirakashi 2, Conference bldg., Sendai International Center) | Unique enzymes, metabolism and functions of various microorganisms and their application |
| 3S08 | September 27 | Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center) | Principles of tissue architecture through the understanding of cell community |
| 3S09 | September 27 | Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center) | Large-scale proteome analysis to open a new avenue for biochemical approach |
| 3S10 | September 27 | Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center) | Macrophage diversity in life and disease |
| 3S11 | September 27 | Room 11 (B200, Lecture Rooms B, Kawauchi Campus) | Biology of functional zones in organelles |
| 3S12 | September 27 | Room 12 (B201, Lecture Rooms B, Kawauchi Campus) | A Pivotal Strategy in Biochemistry: In vitro reconstitution |
| 3S13 | September 27 | Room 13 (B202, Lecture Rooms B, Kawauchi Campus) | Lipid dynamics in biological membranes and their physiology |
| 3S14 | September 27 | Room 14 (B203, Lecture Rooms B, Kawauchi Campus) | Regeneration of membrane transport studies ~ clarification of long standing issues |
| 3S15 | September 27 | Room 15 (B204, Lecture Rooms B, Kawauchi Campus) | New development of thiol biology |
| 3S16 | September 27 | Room 16 (B101, Lecture Rooms B, Kawauchi Campus) | Circadian clock as an interface of the environmental stress responses and internal variation |
| 3S17 | September 27 | Room 17 (B102, Lecture Rooms B, Kawauchi Campus) | Multiple RNA control freak CCR4-NOT protein complex revealing novel paradigm of gene expression. |
| 3S18 | September 27 | Room 18 (B103, Lecture Rooms B, Kawauchi Campus) | Lessons in gene expression system from yeast |
| 3S19 | September 27 | Room 19 (B104, Lecture Rooms B, Kawauchi Campus) | Frontline of exosome biology: Closing up functions of glyco-related molecules |
Outline
<How to read the session numbers>
Date+ Abbreviation+ Room
Ex.) 1S02: The 1st day/Symposium/Room 2
Date+ Abbreviation+ Room
Ex.) 1S02: The 1st day/Symposium/Room 2
Day 1 (September 25)
1S01
Date: September 25 16:00-18:30 Place: Room 1 (Main Hall, Conference bldg., Sendai International Center)
Dysregulation of Oxygen Remodeling and Disease Pathogenesis
Organizers: Takaaki Akaike (Tohoku Univ.), Ken Itoh (Hirosaki Univ.)
Supported by Scientific Research on Innovative Areas "Oxygen Biology: a new criterion for integrated understanding of life" of MEXT
Speakers / Outline: ▼
Speakers: Sue Goo Rhee (Yonsei Univ. Coll. of Medicine, Korea), Yasuo Mori (Kyoto Univ.), Takaaki Akaike (Tohoku Univ.), Ken Itoh (Hirosaki Univ.), Yoshito Kumagai (Univ. of Tsukuba), Motohiro Nishida (Okazaki Inst. for Integrative Bioscience)
Outline: Molecular oxygen and reactive oxygen species (ROS) have been formed biologically since the early stages of the evolution of life and played an important role in energy metabolism as well as in signal transduction. Cysteine residues in proteins (i.e. protein thiols) play a major role in oxygen and ROS sensing and many kinds of electrophiles, which are increasingly known as cellular signaling molecules, often share the same cysteine residues as sensors. For optimizing local redox signaling, cells actively regulate redox environments (including oxygen concentration) in tissue- and organelle-specific manners, for which we propose the innovative perspective of “Oxygen Remodeling” that includes hypoxic signaling. In this symposium, we will discuss the dysregulation of “Oxygen Remodeling” and disease pathogenesis.
1S02
Date: September 25 16:00-18:30 Place: Room 2 (Tachibana, Conference bldg., Sendai International Center)
New Horizon of Biochemistry using genome editing technology
Organizers: Satoru Takahashi (Univ. of Tsukuba), Masahito Ikawa (Osaka Univ.), Takashi Yamamoto (Hiroshima Univ.)
Supported by Japanese Association for Laboratory Animal Science
Speakers / Outline: ▼
Speakers: Takashi Yamamoto (Hiroshima Univ.), Hiroshi Nishimasu (The Univ. of Tokyo), Moritoshi Sato (The Univ. of Tokyo), Seiya Mizuno (Univ. of Tsukuba), Masahito Ikawa (Osaka Univ.), Toshiro Sato (Keio Univ.), Akitsu Hotta (Kyoto Univ.)
Outline: Genome editing techniques have already been applied to various analysis of Biochemistry, although further technical modifications are still rtying.We want to introduce the examples of new biochemical analyses by the application of genome editing technology.
1S03
Date: September 25 16:00-18:30 Place: Room 3 (Hagi, Conference bldg., Sendai International Center)
Chemical biology on the biologiccally active compounds
Organizers: Masatoshi Hagiwara (Kyoto Univ.), Minoru Ueda (Tohoku Univ.)
Supported by Japanese Society for Chemical Biology
Speakers / Outline: ▼
Speakers: Masatoshi Hagiwara (Kyoto Univ.), Minoru Ueda (Tohoku Univ.), Masaki Kita (Univ. of Tsukuba), Kazuhisa Sekimizu (The Univ. of Tokyo), Hiroyuki Osada (RIKEN)
Outline: Chemical biology of biologically active molecule is an important area leading to the development of novel drug or herbicide. Recently, the development of chemical biology changes the usage of such molecule in biological research. This symposium will present talks on the chemical biology of bioactive molecule for mammals, plants, insects, microorganisms, and provide the audience an opportunity of the use of such molecules in their own research.
1S04
Date: September 25 16:00-18:30 Place: Room 4 (Sakura 1, Conference bldg., Sendai International Center)
Academia drug discovery
Organizers: Junken Aoki (Tohoku Univ.), Hirotatsu Kojima (The Univ. of Tokyo)
Supported by Platform for Drug Discovery, Informatics and Structural Life Science
Speakers / Outline: ▼
Speakers: Minetaro Arita (Natl. Inst. of Infectious Diseases), Hiroyuki Takeda (Ehime Univ.), Naomi Tsuburaya (The Univ. of Tokyo), Toru Komatsu (The Univ. of Tokyo), Yuya Terashima (The Univ. of Tokyo), Asuka Inoue (Tohoku Univ.), Hiroshi Kaneko (Tohoku Univ.)
Outline: In the 21th century, speed of new drug development has slowed down. In such a situation, expectations of academia drug discovery is increasingly large. In this symposium, we would like to show you some examples of academia drug discovery. In this session, we will have seven presentaions by young investigators who are actually engaged in their own projects.
1S05
Date: September 25 16:00-18:30 Place: Room 5 (Sakura 2, Conference bldg., Sendai International Center)
Multi-omics: new insights into disease biology
Organizers: Tomoyoshi Soga (Keio Univ.), Seizou Koshiba (Tohoku Univ.)
Speakers / Outline: ▼
Speakers: Tomoyoshi Soga (Keio Univ.), Seizou Koshiba (Tohoku Univ.), Shinya Kuroda (The Univ. of Tokyo), Tsuyoshi Osawa (The Univ. of Tokyo), Koji Ueda (Japanese Foundation For Cancer Research)
Outline: In a systems biology construct, diseases are viewed as breakdowns of robustness in biological systems, and disease is developed if damage to biological molecular networks that maintain robustness cannot be repaired. To understand the mechanisms underlying pathogenesis of various diseases and cancer, omics measurement technologies such as genomics, transcriptomics, proteomics and metabolomics are widely employed. Recently, epigenomics technologies that can reveal alterations in DNA methylation and histone modification patterns have been developed. In this symposium, we invite leading researchers, who apply multi-omics or trans-omics technologies to the cutting-edge research focused on pathophysiology and clinical applications.
1S06
Date: September 25 16:00-18:30 Place: Room 6 (Shirakashi 1, Conference bldg., Sendai International Center)
New aspects of the mechanisms underlying diverse cell death and its pathophysiological significances
Organizers: Masato Tanaka (Tokyo Univ. of Pharmacy and Life Sciences), Minoru Tanaka (Natl.l Ctr. for Global Health and Medicine)
Supported by Grants-in-Aid for Scientific Research on Innovative Areas "Dying Code"
Speakers / Outline: ▼
Speakers: Masato Tanaka (Tokyo Univ. of Pharm. and Life Sci.), Minoru Tanaka (Natl. Ctr. for Global Health and Medicine), Hiroyasu Nakano (Toho Univ.), Hirotaka Imai (Kitasato Univ.), Kazunobu Sawamoto (Nagoya City Univ.), Shinichi Sato (Tokyo Inst. of Tech.)
Outline: Cell death has been considered as the final phase of cellular lifetime. However, recent evidences have led to a better understanding of the crucial roles of “signals from dying cell” for multiple biological reactions such as immune response, regeneration and diseases. In addition to apoptosis, new types of cell death called “programmed necrosis” such as Necroptosis and Ferroptosis have been uncovered recently. Thus, cell death study enters into a new phase of comprehensive research on biological phenomena accompanied by cell death together with mechanistic analysis. In this symposium, we would like to discuss recent progress on the molecular mechanisms underlying diverse cell death and its pathophysiological significances as a source of intercellular signaling.
1S07
Date: September 25 16:00-18:30 Place: Room 7 (Shirakashi 2, Conference bldg., Sendai International Center)
Failure of protein structure and the disease: from physical chemistry to clinical medicine
Organizers: Naomi Hachiya (the Tokyo Metropolitan Industrial Technology Research Institute (TIRI)), Noriko Fujiwara (Hyogo Coll. of Medicine)
Speakers / Outline: ▼
Speakers: Naomi Hachiya (the Tokyo Metropolitan Industrial Technology Research Institute (TIRI)), Noriko Fujiwara (Hyogo Coll. of Medicine), Reiko Urade (Kyoto Univ.), Daichi Morimoto (Kyoto Univ.), Masahide Yazaki (Inst. for Biomedical Sciences, Shinshu Univ.), Keiichi Yamaguchi (Gifu Univ.), Norihiko Fujii (Radioisotope research center, Teikyo Univ.), Katsumi Doh-ura (Tohoku Univ.)
Outline: Protein can perform correct function in so far as it has a proper conformation. Therefore, protein synthesis is managed according to the multilayered protein quality control system such as ubiquitin, proteasome and molecular chaperons in cells. This is because of maintaining proper protein conformation, reorganizing and removing misfolded or aggregated polypeptides with pinpoint accuracy. Despite of much effort of studies regarding protein conformation, the means of effective treatments or preventions for the diseases still have not elucidated. In this symposium, we will try to discuss these problems with various viewpoints from different backgrounds and find a new key to solve it.
1S08
Date: September 25 16:00-18:30 Place: Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center)
Adult Stem Cells, Tissue Regeneration and Disease Mechanism
Organizers: Yusuke Yamamoto (National Cancer Center Research Inst.), Shuji Terai (Niigata Univ.)
Speakers / Outline: ▼
Speakers: Hiroshi Nishina (Medical Research Inst., Tokyo Medical and Dental Univ.), Naoki Tanimizu (Sapporo Medical Univ.), Yusuke Yamamoto (National Cancer Center Research Inst.), Ai Kotani (Tokai Univ.), Ryuichi Okamoto (Tokyo Medical and Dental Univ.), Shuji Terai (Niigata Univ.)
Outline: Human body is comprised of more than 270 cell types; approximately 37 trillion cells. Although there are some differences such as turnover speed and rate among tissues, each tissue has stem cells that can maintain the tissues throughout the lifetime. By identifying stem cell markers and their localization in the tissue, stem cell research has rapidly progressed in the last decade. Also, developing culture system of tissue stem cells in vitro, such as 3D modeling has helped to use it as disease model. It has been recently reported that stem cell abnormality due to aging causes diseases such as malignant tumors, therefore stem cell research is not only for regenerative medicine field, but also for application to disease biology.
1S09
Date: September 25 16:00-18:30 Place: Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center)
Recent advances of sirtuin research: From the molecular bases to its roles in diseases
Organizers: Kazuya Yamagata (Kumamoto Univ.), Tadahiro Kitamura (Inst. for Molecular and Cellular Regulation, Gunma Univ.)
Speakers / Outline: ▼
Speakers: Tsutomu Sasaki (Gunma Univ.), Yoshiko Iwai (Univ. of Occupational and Environmental Health), Shu Wakino (Keio Univ.), Takashi Nakagawa (Frontier Research Core for Life Sciences, Univ. of Toyama), Yasuhiro Izumiya (Kumamoto Univ.), Tatsuya Yoshizawa (Kumamoto Univ.)
Outline: Sirtuins, NAD+-dependent protein deacetylases, regulate a wide variety of biological processes, such as metabolism, inflammation, genomic stability, tumorigenesis, and aging. To date, seven sirtuins have been identified in mammals (SIRT1-SIRT7). The roles of seven sirtuins in age-related diseases (e.g. diabetes) and the potential of the sirtuin regulating compounds for the treatment of the diseases are being intensively investigated. In addition, the metabolism of NAD+ has again gained attentions due to its requirement by the enzymatic activities of sirtuins. Until recently, we had no chance to discuss about sirtuins beyond the field of speciality. In this symposium, we would like to discuss about the recent advances of sirtuin research from molecular bases to the significance in diseases.
1S10
Date: September 25 16:00-18:30 Place: Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center)
Intersection of oncology and immunology: Recent progress in the phosphorylation research and its therapeutic application
Organizers: Hiroshi Shima (Miyagl Cancer Ctr., Res. Inst.), Takashi Matozaki (Kobe Univ.)
Speakers / Outline: ▼
Speakers: Masaaki Murakami (Inst. for Genetic Medicine, Hokkaido Univ.), Taku Okazaki (Inst. for Genome Res., Tokushima Univ.), Takashi Matozaki (Kobe Univ.), Masanori Hatakeyama (The Univ. of Tokyo), Takehiko Kamijyo (Saitama Cancer Ctr., Res. Inst.), Hiroshi Shima (Miyagl Cancer Ctr., Res. Inst.)
Outline: Because cancer is caused by an accumulation of gene mutations, it is thought to be genetic disease. On the other hand, cancer has the side of the immune disease, too. This is because that incidence of cancer increases when transformed cells cannot be eliminated by immunological surveillance. Therefore, several trials to apply immunoresponse to cancer treatment had been executed, but were not necessarily as good as expected. However, the situation changed completely by the appearance of the recent immune checkpoint therapy. Since phosphorylation plays essential roles in cancer development and regulation of immune system, understanding of how kinases and phosphatases are regulated in these systems is quite important for the new treatment with a few side effects. We planned this symposium to be the place of interaction of oncology and immunology with a key word protein phosphorylation.
1S11
Date: September 25 16:00-18:30 Place: Room 11 (B200, Lecture Rooms B, Kawauchi Campus)
The origin of Organellostasis
Organizers: Yasushi Tamura (Yamagata Univ.), Kanji Okumoto (Kyushu Univ.)
Speakers / Outline: ▼
Speakers: Yasushi Tamura (Yamagata Univ.), Shigehiko Tamura (Kyushu Univ.), Mikio Nishimura (National Inst. of Basic Biology), Richard Rachubinski (Univ. of Alberta, Canada), Hiromi Sesaki (Johns Hopkins Univ., USA), Osamu Kuge (Kyushu Univ.)
Outline: In eukaryotic cells, highly developed membrane structures called organelles exert specialized functions to maintain cellular vital activities. To maintain characteristic structures/morphology and functions of organelles, organelle constituents such as proteins and lipids have to be transported to appropriate organelles and their internal compartments. Moreover, organelles drastically change their volumes, contents and structures in response to the cellular demands and external environments to exhibit optimized functions.In this symposium, we will introduce the latest findings on “organellostasis", especially in terms of mitochondria and peroxisomes, which play central roles in cellular metabolism, and discuss how organelles achieve the optimized cellular functions and homeostasis.
1S12
Date: September 25 16:00-18:30 Place: Room 12 (B201, Lecture Rooms B, Kawauchi Campus)
Protein complex and protein network from the point of view of motifs
Organizers: Masayuki Seki (Tohoku Pharmaceutical Univ.), Masami Horikoshi (The Univ. of Tokyo)
Speakers / Outline: ▼
Speakers: Masayuki Seki (Tohoku Pharmaceutical Univ.), Masami Horikoshi (The Univ. of Tokyo), Naruhiko Adachi (Inst. of Materials Structure Science, KEK), Motoyori Ohta (Nagoya Univ.), Eiryo Kawakami (RIKEN, IMS), Yu Nakabayashi (Tohoku Pharmaceutical Univ.)
Outline: The main aim of biochemistry is to reveal molecular mechanism behind a variety of biological reactions through the analyses of bio-molecular components, interaction among components, and chemical reaction. In the case of protein, huge numbers of constitutive and regulative protein complex and network among proteins have been partially revealed by global proteomic analyses. Although motifs must support such protein complex and protein network, research of motifs governing protein complex and protein network has not been sufficiently progressed. In this symposium, the studies based on motifs and novel findings on network structure will be presented. The participants on this symposium will hopefully realize that we are in the turning point from old-fashioned biochemistry to new biochemistry.
1S13
Date: September 25 16:00-18:30 Place: Room 13 (B202, Lecture Rooms B, Kawauchi Campus)
High resolution electron microscopy targeted on protein complex analysis
Organizers: Chikara Sato (AIST), Takuo Yasunaga (Kyushu Inst. of Technology)
Speakers / Outline: ▼
Speakers: Andreas Engel (Delft Univ. of Technology, Netherlands), Kazuyoshi Murata (National Inst. for Physiological Sciences), Takuo Yasunaga (Kyushu Inst. of Technology), Kouta Mayanagi (Kyusyu Univ.), Chikara Sato (AIST), Kaoru Mitsuoka (Osaka Univ.), Akihiro Narita (The Structural Biology Research Center, Nagoya Univ.)
Outline: Single particle reconstruction (SPA) is a comprehensive structure determination method, which does not require time-consuming crystal formation. In this method, purified proteins in buffer solution are frozen, and the protein molecules are imaged using cryo-transmission electron microscope. From the projections, the 3D structure is reconstructed using image processing. The amount of the required sample is usually small because the 3D structure is reconstructed from the countable number of projections. Single particle analysis recently reached atomic resolution. SPA combined with electron tomography has also been applied to membrane bound complexes reconstituted in proteoliposomes. This symposium is targeted on the structure of soluble proteins, membrane proteins and their complexes, cytoskeletons and viruses. The advantage and disadvantage of SPA and how to introduce SPA system will be discussed.
1S14
Date: September 25 16:00-18:30 Place: Room 14 (B203, Lecture Rooms B, Kawauchi Campus)
Membrane dynamics-mediated regulation of cellular interactions with extracellular environments
Organizers: Takeshi Kawauchi (Inst. of Biomedical Research and Innovation), Mitsunori Fukuda (Tohoku Univ.)
Speakers / Outline: ▼
Speakers: Takeshi Kawauchi (Inst. of Biomedical Research and Innovation), Hideki Yamaguchi (National Cancer Center Research Inst.), Takuro Tojima (RIKEN Brain Science Inst.), Shigetomo Fukuhara (National Cerebral and Cardiovascular Center Research Inst.), Rikinari Hanayama (Kanazawa Univ.), Mitsunori Fukuda (Tohoku Univ.)
Outline: In multicellular organisms, each cell communicates with extracellular environments, including the neighboring cells and surrounding extracellular matrices (ECMs), to form various tissue structures. Defects in the interaction with extracellular environments result in several diseases, such as cancer. While the cellular interactions are known to require cytoskeletal organization-mediated regulation of cell adhesions, emerging evidence also suggests that the regulation of membrane dynamics, including membrane trafficking and exosomes, plays important roles in the cellular interactions with extracellular environments. In this symposium, six speakers will introduce novel aspects of the regulatory mechanisms for cell-to-cell or cell-to-ECM interactions with particular focus on membrane dynamics.
1S15
Date: September 25 16:00-18:30 Place: Room 15 (B204, Lecture Rooms B, Kawauchi Campus)
Nuclear and chromatin dynamics in human diseases
Organizers: Hitoshi Kurumizaka (Waseda Univ.), Noriko Saitoh (Kumamoto Univ.)
Speakers / Outline: ▼
Speakers: Hitoshi Kurumizaka (Waseda Univ.), Noriko Saitoh (IMEG, Kumamoto Univ.), Yusuke Kishi (The Univ. of Tokyo), Tetsuro Hirose (Inst. for Genetic Medicine, Hokkaido Univ.), Toru Hirota (Cancer Inst. of the JFCR), Nobuyoshi Akimitsu (Isotope Science Center, The Univ. of Tokyo), Tokuko Haraguchi (Advanced ICT Research Inst., NICT)
Outline: The nucleus is compartmentalized for its efficient activities such as transcription. Genomic DNA is folded into higher ordered structure; chromatin. Chromatin is associated with and regulated by its local environment, nuclear structures including nuclear membrane, the nucleolus, speckles and so on. The chromatin and nuclear structures dynamically change in human diseases. Recent studies in biochemistry and medical biology elucidated protein- and RNA- components of chromatin and nuclear structures are associated with human diseases including cancer, infertility, progeria syndrome, and neurological disorders. In this symposium, we will focus on leading researches of nuclear and chromatin dynamics in human diseases, and discuss on pathogenesis and possible diagnostic and therapeutic targets.
1S16
Date: September 25 16:00-18:30 Place: Room 16 (B101, Lecture Rooms B, Kawauchi Campus)
Diversity of Stem /Progenitor Cells for Cardiovascular System and its Implication to Human Diseases
Organizers: Masatsugu Ema (Shiga Univ. of Medical Science), Jun Takeuchi (Inst. of Molecular and Cellular Bioscience, the Univ. of Tokyo)
Speakers / Outline: ▼
Speakers: Masatsugu Ema (Shiga Univ. of Medical Science), Yuka Morita (Inst. of Molecular and Cellular Bioscience, The Univ. of Tokyo), Wataru Kimura (Center for TARA, Tsukuba Univ.), Seitaro Nomura (The Univ. of Tokyo Hospital), Yoshiaki Kubota (Keio Univ.), Ken-ichi Mizutani (Doshisha Univ.), Yosuke Mukoyama (National Inst. of Health, USA)
Outline: Cardiovascular system is the first organ to develop, and supplies oxygen and nutrients in addition to furnish of niche for induction of other tissues. Very recently, new origins and niche for stem /progenitor cells giving rise to heart and blood vessels. It has been found that hypoxic niche is important for the maintenance of adult stem cells. Heart and blood vessels develop in a mutual interaction with neurons, and its failure leads to human diseases. We will discuss the recent progress on the origin, niche for stem /progenitor cells of heart and blood vessels, and its relation to human diseases.
1S17
Date: September 25 16:00-18:30 Place: Room 17 (B102, Lecture Rooms B, Kawauchi Campus)
Eyewitness real-time platelet-fibrin thrombus formation and its lysis at single molecular and cellular levels!
Organizers: Akitada Ichinose (Yamagata Univ.), Hiroyuki Takeya (Sojo Univ.)
Speakers / Outline: ▼
Speakers: Anna Protopopova (Scientific Res. Inst. of Physical-Chemical Medicine, Russia), Kazuo Tanishita (Inst. of Nanoscience and Nanotechnology, Waseda Univ. ), Satoshi Nishimura (Jichi Medical Univ.), Takashi Ito (Kagoshima Univ.), Yuko Suzuki (Hamamatsu Univ. School of Medicine)
Outline: An epoch in the hemostasis and thrombosis field has started: Dr. Protopoporva visualized fibrin network formation at the single molecular level by high-resolution atomic force microscope (ATM). Dr. Tanishita used ATM to measure the adhesive force between von Willebrand factor and platelet glycoprotein Ibα at the single bond level. Dr. Nishimura showed single platelet behaviors in the developing thrombus by multi-photon microscopy. Dr. Ito used a microchip-based flow chamber system to evaluate the thrombogenicity at shear rates experienced in vivo. Finally, Dr. Suzuki demonstrated a unique secretory dynamics of a single granule containing tissue plasminogen activator in a vascular endothelial cell and the fibrinolytic process of platelet-rich microthrombi. Let's eyewitness these all!
1S18
Date: September 25 16:00-18:30 Place: Room 18 (B103, Lecture Rooms B, Kawauchi Campus)
Heating Up: The Emergence of Thermal Biology
Organizers: Masato Umeda (Kyoto Univ.), Kohki Okabe (The Univ. of Tokyo)
Supported by Grant-in-Aid for Scientific Research on Innovative Areas "Thermal Biology"
Speakers / Outline: ▼
Speakers: Kohki Okabe (The Univ. of Tokyo), Makoto Tominaga (Okazaki Inst. for Integrative Bioscience), Shingo Kose (RIKEN), Kazuhiro Nakamura (Nagoya Univ.), Koji Shibasaki (Gunma Univ.), Masato Umeda (Kyoto Univ.)
Outline: Temperature, a key regulator of biochemical reactions, influences important physiological functions. In addition to investigations into the sensing mechanism of temperature, focusing on heat-shock response, temperature-sensitive TRP channels, and cell metabolism, recent intracellular thermometry has revealed that there are significant temperature changes inside of living cells related directly to cellular events, urging a novel field of biology focused on solely temperature, thermal biology, to emerge. This symposium will provide an overview of the latest progress in thermal biology, revealing the coupling of intracellular temperature and cellular functions, and will explore how this fundamental physical parameter contributes to all molecular-based biology.
1S19
Date: September 25 16:00-18:30 Place: Room 19 (B104, Lecture Rooms B, Kawauchi Campus)
Central role of ribosome in gene regulation
Organizers: Toshifumi Inada (Tohoku Univ.), Hideki Taguchi (Tokyo Inst. of Technology)
Speakers / Outline: ▼
Speakers: Toshifumi Inada (Tohoku Univ.), Hideki Taguchi (Tokyo Inst. of Technology), Tsutomu Suzuki (The Univ. of Tokyo), Shintaro Iwaski (Univ. of California, Berkeley, USA), Motomasa Tanaka (RIKEN, BSI)
Outline: Ribosome plays crucial roles in gene regulation to ensure the proper expression. Recent studies have revealed that the precise control of translation elongation rates plays crucial roles in proper folding and translocation of proteins. Moreover, errors in translation elongation induce the specific modifications of ribosomes that lead to rapid degradation of aberrant products and mRNA. This symposium will focus on the central roles of ribosome in post-transcriptional gene expression.
Day 2 (September 26)
2S01
Date: September 26 16:00-18:30 Place: Room 1 (Main Hall, Conference bldg., Sendai International Center)
Integration mechanisms of extracellular environments into transcription and epigenomes
Organizers: Akiyoshi Fukamizu (Univ. of Tsukuba), Toshikazu Ushijima (Natl. Cancer Ctr. Res. Inst.)
Speakers / Outline: ▼
Speakers: Toshikazu Ushijima (Natl. Cancer Ctr. Res. Inst.), Kazuhiko Igarashi (Tohoku Univ.), Akiyoshi Fukamizu (Univ. of Tsukuba), Atsushi Suzuki (Kyushu Univ.), Yasuhiro Yamada (Kyoto Univ.)
Outline: Transcription forms an epigenome, and an epigenome regulates transcription. A loop of transcription and an epigenome is formulated formed based on a pre-existing loop and extracellular environment during development and differentiation, and functions as a cellular memory. At the same time, a drastic change in transcription may change an epigenome and erase cellular memory. Even in a steady state, extracellular signals, such as stress, can modify a loop, and accumulation of irreversible changes leads to various diseases. Recent genome-wide analyses and single cell analyses have revealed regulators of a loop, in addition to the players in the loop, such as transcription factors, histone modifications, and DNA methylation. It is also becoming clear how and what extracellular environments influence a loop. In this symposium, we will discuss loops in multiple phases of a life, and try to extract a principle of how extracellular environments are incorporated into a loop of transcription and an epigenome.
2S02
Date: September 26 16:00-18:30 Place: Room 2 (Tachibana, Conference bldg., Sendai International Center)
Diabetes as disturbed states of systemic glucose metabolism
Organizers: Hideki Katagiri (Tohoku Univ.), Tomoichiro Asano (Hiroshima Univ.)
Supported by The Japan Diabetes Society
Speakers / Outline: ▼
Speakers: Satoshi Nishimura (Jichi Medical Univ.), Michihiro Matsumoto (Natl. Ctr. for Global Health and Medicine), Akira Uruno (Tohoku Univ.), Yusuke Nakatsu (Hiroshima Univ.), Hideki Katagiri (Tohoku Univ.)
Outline: Metabolism is coordinated and regulated among different organs/tissues throughout the body. Communication among organs/tissues is extremely important for maintaining systemic homeostasis. Mechanisms of metabolic regulations in each organ/tissue as well as inter-organ metabolic communication are now elucidating. In addition, diabetes, obesity and metabolic syndrome are identified as the disturbed states of these metabolic regulation systems. Therefore, in this symposium co-hosted by The Japanese Association of Medical Sciences and The Japan Diabetes Society, we will discuss both physiological and pathological states of glucose metabolism through the achievements of leading-edge research.
2S03
Date: September 26 16:00-18:30 Place: Room 3 (Hagi, Conference bldg., Sendai International Center)
Genome analyses and biochemistry
Organizers: Jun Yasuda (Tohoku Univ.), Kengo Kinoshita (Tohoku Univ.)
Speakers / Outline: ▼
Speakers: Yutaka Watanabe (Illumina), Jonas Korlach (Pacific Biosciences), Masateru Taniguchi (Osaka Univ.), Itoshi Nikaidou (RIKEN), Masahiro Hiratsuka (Tohoku Univ.), Jun Yasuda (Tohoku Univ.)
Outline: The advent of next generation sequencer (NGS) has brought us a revolution in biomedical sciences. Low cost NGS technologies will realize the precision medicine. The technological development of NGS has been owed to the conventional biochemical knowledge and development. For example, chemical synthesis of fluorescent-labeled nucleic acids or strand-replacement DNA polymerases is applied to the sequencer technologies. The knowledge of enzymology has provided the precise annotations of the DNA variants in a genome. This symposium will focus on the relation between biochemistry and NGS technology and give an insight for the integration of information science and classical biochemical ideas.
2S05
Date: September 26 16:00-18:30 Place: Room 5 (Sakura 2, Conference bldg., Sendai International Center)
Biology of chronic inflammation
Organizers: Takehiko Yokomizo (Juntendo Univ.), Akihiko Yoshimura (Keio Univ.)
Supported by AMED, Advanced Research and Development Programs for Medical Innovation（AMED-CREST）
Speakers / Outline: ▼
Speakers: Makoto Murakami (Tokyo Metro. Inst. of Med. Sci.), Makoto Arita (RIKEN), Takashi Shichita (Keio Univ.), Susumi Nakae (The Univ. of Tokyo), Koji Atarashi (Keio Univ.)
Outline: The inflammation, in vivo reaction based on infiltration of immune cells, has been considered a biological defense mechanism against infection or tissue injury. However in recent years, chronic inflammation are strongly suggested to be involved in various diseases such as cancer, arteriosclerosis, obesity, Alzheimer's disease. However, its molecule and cellular mechanisms remains unclear. In this symposium, the most up-to-date information at the molecular and cellular mechanisms of chronic inflammation and allergy by bioactive lipids, intestinal bacteria and tissue injury will be provided form young researchers leading this field.
2S06
Date: September 26 16:00-18:30 Place: Room 6 (Shirakashi 1, Conference bldg., Sendai International Center)
Redox signals regulating organelle environment
Organizers: Motohiro Nishida (Okazaki Inst. for Integrative Biosci. (NIPS)), Yoshito Kumagai (Univ. of Tsukuba)
Speakers / Outline: ▼
Speakers: Takashi Uehara (Okayama Univ.), Kazuhito Tomizawa (Kumamoto Univ.), Hideki Sumimoto (Kyushu Univ.), Koji Uchida (Nagoya Univ.), Yasuhiro Shinkai (Univ. of Tsukuba)
Outline: Cellular homeostasis is precisely regulated by organelle-organelle communications. Current consensus is that endogenous and exogenous electrophiles such as oxygen-derived reactive species and environmental pollutants induce organelle remodeling and increase cellular toxicity. We regard electrophiles as a unique mediator to form organelle network, and five researchers will introduce their cutting-edge researches on chemical and biological properties of electrophiles and their functions on organelles, and molecular mechanisms underlying induction of organelle toxicity by electrophilic modifications of specific proteins. We also aim to suggest a new concept leading to development of innovative strategy to predict or diagnose a risk of ahead sick, based on redox biology.
2S07
Date: September 26 16:00-18:30 Place: Room 7 (Shirakashi 2, Conference bldg., Sendai International Center)
Advanced research of unique toxin/venom-related animals based on Venomics project
Organizers: Tomohisa Ogawa (Tohoku Univ.), Hiroki Shibata (Medical Inst. of Bioregulation, Kyushu Univ.)
Speakers / Outline: ▼
Speakers: Tomohisa Ogawa (Tohoku Univ.), Hiroki Shibata (Medical Inst. of Bioregulation, Kyushu Univ.), Eiich Shoguchi (OIST), Chuya Shinzato (OIST), Jun Wang (Beijing Genomics Inst., China), Keijyu Okano (Akita Pref. Univ.)
Outline: Among the various organisms, venomous animals are very unique because they can produce multiple toxin molecules for caputuring prey. These molecules are very specific for target of biological system including human. Thus, the toxic ingredients have been used for investigation of complex biological systems as tools, and seeds of drug discovery. Recently, omics analyses including genome of venomous animals (Venomics) have been conducted to disclose highly divergent profiles of venome-related genes, unique venomous systems. In this symposium, we will focus on the venomics project for several venomous animals such as snakes, spider, marine invertebrate and insects, and will be discussed from the viewpoint of evolution, genomics, and biological chemistry of toxins.
2S08
Date: September 26 16:00-18:30 Place: Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center)
Hematopoiesis and Environment
Organizers: Takashi Kato (Waseda Univ.), Wataru Nunomura (Akita Univ.)
Speakers / Outline: ▼
Speakers: Wataru Nunomura (Akita Univ.), Daisuke Sugiyama (Kyushu Univ.), Ritsuko Shimizu (Tohoku Univ.), Kenichi Miharada (Lund Univ., Sweden), Keiyo Takubo (National Center for Global Health and Medicine), Takashi Kato (Waseda Univ.)
Outline: Hematopoiesis is one of fundamental regulatory systems in vertebrates. With hope for developing new perspectives, we will discuss issues of hematopoietic regulation under the alteration in the environment, together with the places of hematopoiesis. Concerning erythropoiesis, the evolutional significance of erythroid enucleation (by Nunomura) and transcriptional regulation directed by GATA1-cistrome (by Shimizu) will be addressed. In mammalian fetal hematopoiesis, molecular niche (by Sugiyama) and hematopoietic regulation by bile acids (by Miharada) will be introduced. The subsequent adult hematopoietic response to environmental stress will be talked over by Takubo. Finally, a new approach for navigating environmental response of hematopoiesis in amphibian models will be given by Kato.
2S09
Date: September 26 16:00-18:30 Place: Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center)
Hypoxia and Disease
Organizers: Norio Suzuki (Tohoku Univ.), Masaomi Nangaku (The Univ. of Tokyo)
Supported by Grant-in-Aid for Scientific Research on Innovative Areas “Oxygen biology” from MEXT, Japan.
Speakers / Outline: ▼
Speakers: Norio Suzuki (Tohoku Univ.), Masaomi Nangaku (The Univ. of Tokyo), Yoji Andrew Minamishima (Keio Univ.), Nobuhito Goda (Waseda Univ.), Randall S. Johnson (Univ. of Cambridge, UK)
Outline: Reduced oxygen supply (hypoxia) to cells causes dramatic changes in gene expression profiles through the activation of hypoxia-inducible transcription factors (HIFs), which are required for cellular adaptation to hypoxic conditions. Recent studies on HIF regulatory mechanisms have revealed that hypoxia response systems regulate various cellular events besides adaptation to hypoxia. The altered regulation of hypoxia response systems is closely related to the onset and/or progression of human diseases, including inflammation and cancer. To thoroughly understand the pathophysiology of these systems, we discuss the recent findings about hypoxia response
systems and the cooperation between their regulatory networks and other cellular pathways.
systems and the cooperation between their regulatory networks and other cellular pathways.
2S10
Date: September 26 16:00-18:30 Place: Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center)
Proteostasis and age-related diseases
Organizers: Akira Nakai (Yamaguchi Univ.), Yoshitaka Nagai (Osaka Univ.)
Speakers / Outline: ▼
Speakers: Toshihide Takeuchi (Osaka Univ.), Masafumi Yohda (Tokyo Univ. of Agriculture and Technology), Itoh Hideaki (Akita Univ.), Hideki Yashiroda (The Univ. of Tokyo), Fuminori Tokunaga (Osaka City Univ.), Akira Nakai (Yamaguchi Univ.)
Outline: Cellular functions are carried out by a lot of different proteins. Newly synthesized proteins are correctly folded by chaperones, and a substantial proportion of these proteins are also misfolded and degraded by proteasome and so on. Proteostasis, or a state of proteome balance, is maintained through regulation of the synthesis, folding, and clearance of individual proteins. Dysregulation of proteostasis networks in a wide range of environmental and metabolic conditions is tightly associated with aging, age-related neurodegenerative diseases and cancers. In this symposium, we show recent advances in mechanisms of proteostasis regulation. Based on novel mechanisms of protein folding by chaperone, degradation by proteasome, and transcriptional regulation of proteostasis network pathways, we will look over the proteostasis networks within cells and to discuss about pathophysiology of age-related diseases.
2S11
Date: September 26 16:00-18:30 Place: Room 11 (B200, Lecture Rooms B, Kawauchi Campus)
Organelle homeostasis; Organelle stress response and crosstalk between organelles
Organizers: Ryo Ushioda (Kyoto Sangyo Univ.), Hiderou Yoshida (Univ. of Hyogo)
Speakers / Outline: ▼
Speakers: Ryo Ushioda (Kyoto Sangyo Univ.), Hiderou Yoshida (Univ. of Hyogo), Hideki Nishitoh (Univ. of Miyazaki), Claudio Hetz (Univ. of Chile, Chile), Fumika Koyano (Tokyo Metropolitan Inst. of Medical Science), Hitoshi Nakatogawa (Tokyo Inst. of Technology), Kohei Arasaki (Tokyo Univ. of Pharmacy and Life Sciences), Tatsuya Saitoh (Tokushima Univ.)
Outline: Each of cell organelles is provided with the sensing/response mechanisms against various stresses, the signals of which are transduced to other organelles beyond the membranes. Dysfunctions of these signal transductions are supposed to disrupt the organelle homeostasis and cause serious disorders. Recently, the contact sites between the organelles have been identified and reported to play essential roles for organelle cooperation, signal transduction, membrane production and so on. In this symposium, we focus on the mechanisms for the organelle stress responses and the crosstalk among the organelles for understanding the complex mechanisms of organelle homeostasis.
2S12
Date: September 26 16:00-18:30 Place: Room 12 (B201, Lecture Rooms B, Kawauchi Campus)
Dynamics of protein complex for cellular robustness
Organizers: Tsuyoshi Ikura (RBC, Kyoto Univ.), Kanji Furuya (RBC, Kyoto Univ.)
Speakers / Outline: ▼
Speakers: Tsuyoshi Ikura (RBC, Kyoto Univ.), Hozumi Motohashi (IDAC, Tohoku Univ.), Kanji Furuya (RBC, Kyoto Univ.), Takuma Shiraki (Kinki Univ.), Satoshi Tashiro (Hiroshima Univ.)
Outline: Drastic change in extracellular environment could induce the change in cellular functions. However cells posses the ability to keep its cellular integrity, and is called cellular robustness. The cellular robustness is conferred by dynamic change in protein or metabolic network in the cells, however what underlies is still undefined.The protein network is composed of cooperative actions of various protein complexes, and thus the dynamic change in protein complexes themselves in turn could define the dynamics of the protein network. Here, in this symposium, we will discuss the possibilities of biochemical approach to understand the underlying system of the dynamic change in the protein network, which controls cellular robustness.
2S13
Date: September 26 16:00-18:30 Place: Room 13 (B202, Lecture Rooms B, Kawauchi Campus)
Emerging roles of Arf and Arl family (G protein) in development, neurological functions, tumorigenesis, and metastasis.
Organizers: Toshio Watanabe (Nara Women’s Univ.), Kenji Kontani (Meiji Pharmaceutical Univ.)
Speakers / Outline: ▼
Speakers: Yasunori Kanaho (Univ. of Tsukuba), Yohei Yamauchi (Univ. of Tsukuba), Shinji Matsumoto (Osaka Univ.), Natsuki Hayakawa (Nara Women’s Univ.), Yohei Katoh (Kyoto Univ.), Keisuke Hashimoto (The Univ. of Tokyo)
Outline: It's well known that members of Arf and Arl family (G protein) affect the morphologies of organelles, such as the Golgi apparatus and early endosomes, and regulate protein trafficking through the secretory and endocytic pathways. However, little is known about their physiological functions as well as how these molecules relate with diseases such as cancer or neurological disorders. Recent studies are revealing that Arf and Arl family are involved in development, neurological functions, tumorigenesis, metastasis, and tumor angiogenesis. Thus, new roles of Arf and Arl proteins are now emerging. Based on these, new treatment strategies aiming at development of an anticancer drug and a disease curative drugs are also going on. In this Symposium, young researchers at the front line in this research field present the latest knowledge about Arf and Arl family, as well as views to the future about the clinical applications.
2S14
Date: September 26 16:00-18:30 Place: Room 14 (B203, Lecture Rooms B, Kawauchi Campus)
Innovative Bio-science into molecular mechanism of membrane proteins
Organizers: Seiji Kojima (Nagoya Univ.), Hiroshi Suzuki (Asahikawa Medical Univ.)
Speakers / Outline: ▼
Speakers: Seiji Kojima (Nagoya Univ.), Haruo Ogawa (Inst. of Molecular and Cellular Bioscience, The Univ. of Tokyo), Hiroshi Suzuki (Asahikawa Medical Univ.), Kazuhiro Abe (Cellular and Structural Physiology Inst., Nagoya Univ.), Chigusa Kobayashi (RIKEN, AICS), Takayuki Nishizaka (Gakushuin Univ.), Akihito Yamaguchi (Osaka Univ.)
Outline: To answer the fundamental question in Bio-science; how proteins accomplish function, we need to understand the coupling between each elementary reaction process and structural change in the protein of interest. In the case of membrane proteins, it has been quite difficult to detect and/or analyze the changes at a single molecule level and to obtain its high-resolution structure; therefore our knowledge of the molecular mechanism of membrane proteins is still limited. In this symposium, we focus on the frontier studies of membrane proteins to overcome its inherent difficulties by distinct and innovative approaches including a single molecule analysis, molecular dynamics simulation, atomic-level structural studies, and molecular dissection in advanced biochemistry.
2S15
Date: September 26 16:00-18:30 Place: Room 15 (B204, Lecture Rooms B, Kawauchi Campus)
Protein-Nucleic Acid Interaction Regulating the Genome Maintenance and Inheritance
Organizers: Hisao Masai (Tokyo Metro. Inst. of Medical Science), Tsutomu Katayama (Kyushu Univ.)
Speakers / Outline: ▼
Speakers: Yoshizumi Ishino (Kyushu Univ.), Kaoru Sugasawa (Kobe Univ.), Hiroshi Iwasaki (Tokyo Inst. of Technology), Masato Kanemaki (National Inst. of Genetics), Tsutomu Katayama (Kyushu Univ.), Hiroyuki Araki (National Inst. of Genetics), Hisao Masai (Tokyo Metro. Inst. of Medical Science), Tatsuya Hirano (RIKEN)
Outline: Stable maintenance of genome depends on coordinated execution of replication, recombination, repair and partition of chromosomal DNA. Ultimate understanding of the whole process requires elucidation of molecular basis of protein-nucleic acids and protein-protein interactions that constitute these processes. Two biochemical approaches have been applied toward this goal. One is to first establish the chromosome events in a test tube with crude materials and eventually break down the system to purified components. The other is to biochemically define the functions of each essential factor and eventually reconstitute the system. In this symposium, we will introduce latest progresses achieved by both approaches and would like to discuss the future direction of biochemistry of genome science.
2S16
Date: September 26 16:00-18:30 Place: Room 16 (B101, Lecture Rooms B, Kawauchi Campus)
Roles of vascular systems in the maintenance of homeostasis
Organizers: Tetsuro Watabe (Tokyo Medical and Dental Univ.), Nobuyuki Takakura (Osaka Univ.)
Speakers / Outline: ▼
Speakers: Tetsuro Watabe (Tokyo Medical and Dental Univ.), Nobuyuki Takakura (Osaka Univ.), Yasufumi Sato (Tohoku Univ.), Takashi Minami (Kumamoto Univ.), Akiyoshi Uemura (Nagoya City Univ.), Injune Kim (KAIST, Korea)
Outline: Blood vessels play central roles in the maintenance of body homeostasis, and exhibit differential characteristics in various organs. Blood vessels change their characteristics upon the environmental cues in physiological and pathological conditions. Thus, elucidation of the mechanisms underlying this active homeostasis of vascular systems is important not only for understanding the physiological events, but also for developing novel therapeutic strategies for various diseases such as cancer and retinopathy. In this symposium, researchers from various backgrounds including vascular biology, genetics and cancer biology will introduce novel approaches to study this new field of vascular biology.
2S17
Date: September 26 16:00-18:30 Place: Room 17 (B102, Lecture Rooms B, Kawauchi Campus)
New aspects of signaling molecules in bacterial two-component regulatory systems that elicit adaptive responses to environments
Organizers: Eiji Kinoshita (Hiroshima Univ.), Yoko Eguchi (Kindai Univ.)
Speakers / Outline: ▼
Speakers: Yoko Eguchi (Kindai Univ.), Emiko Kinoshita (Hiroshima Univ.), Yashuhisa Mizutani (Osaka Univ.), Kenich Kitanishi (RIKEN Spring-8 Center), Kaneyoshi Yamamoto (Hosei Univ.), Ryutaro Utsumi (Kindai Univ.)
Outline: One mode of bacterial signal transduction involves two-component systems mediated by phosphorylation of His and Asp residues. The chemical instability of phosphate groups on these residues hampers research on protein phosphorylation in such systems. Phos-tag technology, an approach to research on protein phosphorylation, can be applied to the systems to identify aspects relevant to signaling molecules, including kinetic properties in phosphotransfer and autophosphorylation. This symposium focuses on regulatory mechanisms of signaling molecules in two-component systems, pertinent to responses of bacteria to their environments. Our goals are to demonstrate the impact of research on two-component systems and to highlight recent achievements in structural analysis and drug-discovery research.
2S18
Date: September 26 16:00-18:30 Place: Room 18 (B103, Lecture Rooms B, Kawauchi Campus)
Cutting edge of imaging technologies for neurobiology research
Organizers: Izumi Oinuma (Univ. of Hyogo), Takahiko Matsuda (Inst. for Virus Research, Kyoto Univ.)
Speakers / Outline: ▼
Speakers: Dan Ohtan Wang (Inst. for Integrated Cell-Material Sciences, Kyoto Univ.), Takahiko Matsuda (Inst. for Virus Research, Kyoto Univ.), Izumi Oinuma (Univ. of Hyogo), Mikihiro Shibata (Kanazawa Univ.), Masayuki Sakamoto (The Univ. of Tokyo), Douglas Kim (HHMI Janelia Research Campus, USA)
Outline: Recent advances in labeling and imaging technologies have facilitated the visualization of molecular and cellular events that are invisible with classical techniques. In this symposium, we plan to discuss the cutting-edge of labeling and imaging technologies for neurobiology research, focusing on how to visualize molecular and cellular events in “living" neurons. The speakers will talk about how to visualize endogenous RNAs, endogenous proteins, ultrafine cellular structures, membrane potential dynamics, and calcium dynamics, in living neurons. Although we will discuss the technologies used in neurobiology research, most of them can be applied to other tissues and organs. Therefore, researchers who are not in the field of neuroscience, are also welcome to participate in this symposium.
2S19
Date: September 26 16:00-18:30 Place: Room 19 (B104, Lecture Rooms B, Kawauchi Campus)
Potential of antibodies at new frontiers: Hot topics for liberating the potential of antibodies
Organizers: Yuji Ito (Kagoshima Univ.), Mitsuo Umetsu (Tohoku Univ.)
Supported by AMED, Basic Science and Platform Technology Program for Innovative Biological Medicine
Speakers / Outline: ▼
Speakers: Shohei Koide (Univ. of Chicago & New York Univ., USA), Junho Chung (Seoul National Univ., Korea), Yukinari Kato (Tohoku Univ.), Akiichi Murakami (Univ. of the Ryukyu), Kensaku Sakamoto (RIKEN, SSBC), Yuji Ito (Kagoshima Univ.)
Outline: Antibodies have been widely used as detection reagents and also molecular targeting therapeutics in recent years because of their particularly high molecular recognition ability. Given the fundamentally broad functions of antibodies, their areas of application could be further expanded. However, to develop new fields of application of antibodies, it is necessary to fulfill the functions and other properties imposed by the purposes of specific fields. In this symposium, we will discuss the latest development with lectures given by leaders in these endeavors, with a particular focus on new applications of antibodies and technological strategies to achieve the required functionalities.
Day 3 (September 27)
3S01
Date: September 27 9:00-11:30 Place: Room 1 (Main Hall, Conference bldg., Sendai International Center)
Autophagy machinery and function
Organizers: Noboru Mizushima (The Univ. of Tokyo), Masaaki Komatsu (Niigata Univ.)
Supported by JSPS KAKENHI, Grant-in-Aid for Scientific Research on Innovative Areas, "Multidisciplinary research on autophagy: from molecular mechanisms to disease states"
Speakers / Outline: ▼
Speakers: Yoshinori Ohsumi (Tokyo Inst. of Tech.), Noboru Mizushima (The Univ. of Tokyo), Tamotsu Yoshimori (Osaka Univ.), Masaaki Komatsu (Niigata Univ.), Miyuki Sato (Gunma Univ.), Koji Yamano (Tokyo Metro. Inst. of Med. Sci.)
Outline: Autophagy is a protein degradation system, in which cytoplasmic constituents are transported to lysosomes to be degraded. Discovery of a series of autophagy-related genes (ATGs) in 1990’s has extremely accelerated studies on autophagy. During the past two decades, not only molecular mechanisms but also physiological roles of autophagy have been unveiled, but several basic mechanisms of autophagy remain unsolved. Moreover, a recent growing body of evidence shed light on the importance of unexpected roles of autophagy such as selective removal of damaged organelles and invasive microbes, increasing its complexity. It also turned out that dysregulation of autophagy is directly linked to life-threatening diseases including neurodegeneration and cancer. In this symposium, we demonstrate the latest achievement and discuss the perspective of autophagy research.
3S02
Date: September 27 9:00-11:30 Place: Room 2 (Tachibana, Conference bldg., Sendai International Center)
Disorder of iron metabolism：disease and pathophysiology
Organizers: Shinya Toyokuni (Nagoya Univ.), Hideo Harigae (Tohoku Univ.)
Supported by Japanese Society of Hematology
Speakers / Outline: ▼
Speakers: Des Richardson (The Univ. of Sydney, Australia), Shinya Toyokuni (Nagoya Univ.), Tohru Fujiwara (Tohoku Univ.), Masayoshi Kobune (Sapporo Medical Univ.), Hiroshi Kawabata (Kyoto Univ.)
Outline: Iron is an essential metal not only for oxygen delivery, but also for proliferation of cells, metabolizing drugs, while it is a very toxic metal producing reactive oxygen species (ROS). It is well-known that iron overload causes organ failure and cancer; however, the molecular mechanism is not completely clarified. Recently, molecules involving iron metabolism have been identified by establishment of animal models and the development of next generation sequencing, contributing to understanding of human iron related diseases. In this symposium, novel findings regarding pathophysiology of diseases caused by disorders of iron metabolism will be introduced, and the perspective of clinical and basic research for iron related diseases will be discussed.
3S03
Date: September 27 9:00-11:30 Place: Room 3 (Hagi, Conference bldg., Sendai International Center)
Molecular basis for age-associated stem cell changes and diseases
Organizers: Atsushi Iwama (Chiba University), Naoko Ohtani (Tokyo Univ. of Science)
Supported by Grant-in-aid for Scientific Research on Innovative Areas "Stem Cell aging and disease"
Speakers / Outline: ▼
Speakers: Atsushi Iwama (Chiba Univ.), Shinsuke Yuasa (Keio Univ.), Naoko Ohtani (Tokyo Univ. of Sci.), Ichiro Manabe (The Univ. of Tokyo), Masashi Sanada (Nagoya Medical Center)
Outline: Given that the number of patients suffering from aging-related diseases are increasing rapidly in this super-aged society, a scientific approach that targets aging-related diseases is required to achieve health and long life. We would like to present recent advances in research on stem cell aging and age-associated stem diseases.
3S04
Date: September 27 9:00-11:30 Place: Room 4 (Sakura 1, Conference bldg., Sendai International Center)
Exploring new oxygen biology with cutting-edge imaging technologies
Organizers: Yasuteru Urano (The Univ. of Tokyo), Yasuo Mori (Kyoto Univ.)
Supported by MEXT, Grant-in-Aid for Scientific Research on Innovative Areas "Oxygen biology"
Speakers / Outline: ▼
Speakers: Yousuke Hirakawa (The Univ. of Tokyo), Yousuke Funato (Osaka Univ.), Yuki Sugiura (Keio Univ.), Koshu Okubo (Keio Univ.), Reiko Sakaguchi (Kyoto Univ.), Keitaro Umezawa (The Univ. of Tokyo)
Outline: Molecular oxygen is essential for aerobic organisms. In recent years, some different features and roles of molecular oxygen to realize “life” are extensively elucidated, especially using living cells, organs, and animals. For these experiments, development of cutting-edge imaging technologies to visualize, measure and quantify oxygen concentration, temperature, redox-related bio-molecules and biological responses in living samples is quite important. In this symposium, young and energetic researchers will have talks about their recent achievements of the development of novel imaging technologies and their application to living samples to unlock nature of life from the viewpoint of oxygen biology. Every researcher is highly welcome, if you want to utilize these cutting-edge technologies, to develop novel ones for your own sake, and to discuss the future of oxygen biology.
3S05
Date: September 27 9:00-11:30 Place: Room 5 (Sakura 2, Conference bldg., Sendai International Center)
Development of molecularly targeted cancer drugs by fusion of different fields
Organizers: Tetsuo Noda (Japanese Foundation For Cancer Research), Minoru Yoshida (RIKEN)
Supported by Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT)
Speakers / Outline: ▼
Speakers: Motoharu Seiki (Kanazawa Univ.), Hiroki Nagase (Chiba Cancer Center), Shigeo Ohno (Yokohama City Univ.), Akira Suzuki (Kyushu Univ.), Yutaka Kondo (Nagoya City Univ.), Stefan Knapp (Univ. of Oxford, UK)
Outline: Cancer is the leading cause of death in Japan, and development of innovative cancer medicine is strongly required. In order to meet such a social request, “MEXT/AMED Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT)” and the following AMED project have been carried out since FY 2011 and FY 2016, respectively, for accelerating cancer research from basic phase to practical application. In this symposium, successful examples of drug development in these academic activities will be presented, and the Structural Genomics Consortium（SGC）will be introduced as a representative overseas example of drug development activity in academia.
3S06
Date: September 27 9:00-11:30 Place: Room 6 (Shirakashi 1, Conference bldg., Sendai International Center)
Making the most out of structures -Critical role of structural information in modern life science research-
Organizers: Junichi Takagi (Osaka Univ.), Osamu Nureki (The Univ. of Tokyo)
Speakers / Outline: ▼
Speakers: Junichi Takagi (Osaka Univ.), Hiroaki Suga (The Univ. of Tokyo), Osamu Nureki (The Univ. of Tokyo), Junken Aoki (Tohoku Univ.), So Iwata (Kyoto Univ.), David Drew (Stockholm Univ., Sweden)
Outline: Once regarded as a rather “special” research discipline, structural biology has become a popular and important technology that takes place in almost every corner of biomedical research sectors. Structural biologists are working very closely with researchers of different discipline to derive accurate molecular structures for biologically and medically important proteins, and turning them into a fundamental knowledge that takes us to much higher level of understanding of the life. In this symposium, we will hear three structural topics, each presented by a pair of researchers who collaborated by providing different research expertise. We hope to deliver a message that the sophisticated use of structural information obtained through multidisciplinary approaches will become even more important to the promotion of life science, for the good of humanity.
3S07
Date: September 27 9:00-11:30 Place: Room 7 (Shirakashi 2, Conference bldg., Sendai International Center)
Unique enzymes, metabolism and functions of various microorganisms and their application
Organizers: Hiroshi Takagi (Nara Inst. of Science and Technology), Michihiko Kobayashi (Univ. of Tsukuba)
Speakers / Outline: ▼
Speakers: Hiroshi Takagi (Nara Inst. of Science and Technology), Michihiko Kobayashi (Univ. of Tsukuba), Makoto Ito (Kyushu Univ.), Toru Nakayama (Tohoku Univ.), Hisaaki Mihara (Ritsumeikan Univ.), Hisashi Hemmi (Nagoya Univ.)
Outline: Microorganisms consist of Bacteria, Archaea and Eucarya. Their habitats and functions are diverse. The microbial research interests encompass various fields. In the cells, not only amino acids, but also lipids and biologically active substances including vitamins are involved in the life activity. To clarify the metabolism of these substances by microorganisms and their unique enzymatic functions is important for various aspects. In this symposium, we will widely introduce the forefront topics on novel and unique metabolisms and enzymes on the mechanism of catalytic reaction, the regulation of expression and activity and the physiological function using biochemical approaches. We will also discuss the roles of such studies on basic science and industrial applications.
3S08
Date: September 27 9:00-11:30 Place: Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center)
Principles of tissue architecture through the understanding of cell community
Organizers: Keiyo Takubo (Natl.l Ctr. for Global Health and Medicine), Toshiro Sato (Keio Univ.)
Supported by JSPS KAKENHI, Grant-in-aid for Scientific Research on Innovative Areas, "Stem Cell aging and disease"
Speakers / Outline: ▼
Speakers: Kenshiro Hara (Tohoku Univ.), Nobuo Sasaki (Keio Univ.), Hiroshi Kobayashi (National Center for Global Health and Medicine), Minoru Takasato (Murdoch Childrens Research Inst., Australia), Erina Kuranaga (RIKEN, CDB)
Outline: Cell community is constructed and maintained by tissue stem cell system. Elucidation of the building and homeostatic processes for cell community is critical for understanding of tissue architecture during development and pathological settings. In this symposium, young academic talents gather to share cutting-edge knowledge for these processes. The dynamics and regulation of testis (by Hara) and intestine (by Sasaki) by stem cell system will be presented. The regulatory mechanism of bone marrow by hematopoietic and mesenchymal stem cells (by Kobayashi) will be introduced. Takasato will give a talk on a novel organoid technology for kidney from pluripotent stem cells. Finally, a novel imaging approach for tissue morphogenesiss will be talked over by Kuranaga.
3S09
Date: September 27 9:00-11:30 Place: Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center)
Large-scale proteome analysis to open a new avenue for biochemical approach
Organizers: Hiroyuki Kaji (AIST), Koji Ueda (Japanese Foundation for Cancer Research)
Speakers / Outline: ▼
Speakers: Keiichi Nakayama (Kyushu Univ.), Sumio Otsuki (Kumamoto Univ.), Tatsuya Sawasaki (Ehime Univ.), Shuichi Shimma (Osaka Univ.), Mariko Okada (RIKEN), Yasushi Ishihama (Kyoto Univ.), Hiroyuki Kaji (AIST)
Outline: To reveal the mechanism of a certain biological phenomenon, we'll compare the states of cells before and after stimulus or gene mutation etc. To detect the effect, some proteins selected by a hypothesis are analyzed; however, it is difficult to conclude that the changed protein is responsible for the phenomenon. To answer such question, OMICS based on the comprehensive and non-hypothesis-driven analysis have emerged for the last decades. Twenty years has passed since a term “Proteome" was published. In this period, the technologies on proteomics developed rapidly. In this symposium, cutting-edge of the proteomics and their applications to open a new avenue for biochemical approach will be introduced.
3S10
Date: September 27 9:00-11:30 Place: Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center)
Macrophage diversity in life and disease
Organizers: Ichiro Manabe (Chiba Univ.), Yumiko Oishi (Medical Research Inst., Tokyo Medical and Dental Univ.)
Speakers / Outline: ▼
Speakers: Takashi Satoh (IFReC, Osaka Univ.), Yumiko Oishi (Medical Research Inst., Tokyo Medical and Dental Univ.), Koji Yamanaka (Res. Inst. of Environmental Medicine, Nagoya Univ.), Masanobu Oshima (Kanazawa Univ.), Keisuke Okabe (Keio Univ.), Satoshi Ueha (The Univ. of Tokyo)
Outline: Macrophages were first discovered by Elie Metchnikoff, a Russian bacteriologist, in 1884 as a type of cells that engulfs and digests cellular debris and foreign substances in a process called phagocytosis. It is now clear that macrophages play important physiological roles in development, organ formation, angiogenesis and maintenance of tissue homeostasis, some of which were envisioned by Methnikoff. In addition, macrophage are the major effector cells in chronic inflammation, which is a common pathogenic condition associated with noncommunicable diseases, such as metabolic syndrome, cardiovascular disease and cancer. In this symposium, we would like to discuss the macrophage diversity in physiology and pathology and as a novel therapeutic target.
3S11
Date: September 27 9:00-11:30 Place: Room 11 (B200, Lecture Rooms B, Kawauchi Campus)
Biology of functional zones in organelles
Organizers: Kentaro Hanada (National Inst. of Infectious Diseases), Kazutoshi Mori (Kyoto Univ.)
Speakers / Outline: ▼
Speakers: Kazutoshi Mori (Kyoto Univ.), Kentaro Hanada (National Inst. of Infectious Diseases), Satoshi Goto (Rikkyo Univ.), Akihiro Harada (Osaka Univ.), Kaoru Katoh (AIST), Mie Shimojima (Tokyo Inst. of Technology)
Outline: Organelles accurately accomplish various biological processes in parallel. An individual organelle surrounded by a continuous membrane is considered to be homogenous. However, a new concept is emerging in which distinct functional zones exist in an apparently continuous organelle, and that such zones determine the roles and metabolic destinies of biomolecules. This symposium introduces recent studies on the formation and functions as well as regulation of functional zones in the endoplasmic reticulum and Golgi apparatus from multiple aspects including post-translational modifications and the quality control of proteins, vesicular transport, and organelle contact sites. The biology of functional zones in organelles has the potential to influence various biological fields.
3S12
Date: September 27 9:00-11:30 Place: Room 12 (B201, Lecture Rooms B, Kawauchi Campus)
A Pivotal Strategy in Biochemistry: In vitro reconstitution
Organizers: Hiroaki Imataka (Univ. of Hyogo), Ueda Takuya (The Univ. of Tokyo)
Speakers / Outline: ▼
Speakers: Masayuki Suetsugu (Rikkyo Univ.), Takashi Umehara (RIKEN, CLST), Nono Tomita Takeuchi (The Univ. of Tokyo), Kodai Machida (Univ. of Hyogo), Shinobu Chiba (Kyoto Sangyo Univ.), Junichi Ikenouchi (Kyushu Univ.)
Outline: In vitro reconstitution of biological processes with purified components is a royal road to solving the biochemical mechanisms. Historically, achievements by experts such as reconstitution of enzyme reactions and reconstitution of ribosomes unequivocally advanced understanding of life sciences. Nevertheless, as purifying constituents from cells is a laborious task, young researchers fascinated by expanding molecular biology have gone around this method. Fortunately, however, leading technologies of molecular biology now enable facile preparation of biological factors, reconstitution is emerging again as a pivotal strategy in biochemistry. In this symposium, we will focus on the processes of the central dogma as well as on membranous insertion of nascent peptides and membrane structures.
3S13
Date: September 27 9:00-11:30 Place: Room 13 (B202, Lecture Rooms B, Kawauchi Campus)
Lipid dynamics in biological membranes and their physiology
Organizers: HyeWon Shin (Kyoto Univ.), Jun Suzuki (Immunology Frontier Research Center, Osaka Univ.)
Speakers / Outline: ▼
Speakers: Yuji Hara (Kyoto Univ.), Kazumitsu Ueda (Kyoto Univ.), Kazuma Tanaka (Inst. for Genetic Medicine, Hokkaido Univ.), Keisuke Obara (Hokkaido Univ.), Jun Suzuki (IFReC, Osaka Univ.), HyeWon Shin (Kyoto Univ.)
Outline: Biological membranes composed of lipid bilayers exhibit asymmetric lipid distributions. The stringent regulation of lipid asymmetry is critical for physiological functions such as blood clotting, engulfment of apoptotic cells, secretion of secretory granule, and cell division but the mechanism was not clear. Remarkable progress of recent studies for scramblases, flippases, and floppases is elucidating the mechanism of lipid dynamics in biological membranes and their physiological significance. In this occasion, we organized the symposium for discussing the regulation of lipid dynamics in biological membranes and their physiology in different species. We further discuss the future direction for the field of lipid dynamics.
3S14
Date: September 27 9:00-11:30 Place: Room 14 (B203, Lecture Rooms B, Kawauchi Campus)
Regeneration of membrane transport studies ~ clarification of long standing issues
Organizers: Hiroshi Omote (Okayama Univ.), Tappei Takada (Univ. of Tokyo Hospital)
Speakers / Outline: ▼
Speakers: Shushi Nagamori (Osaka Univ.), Takaaki Miyaji (Advanced Science Res. Ctr., Okayama Univ.), Atsushi Kodan (Inst. for Integrated Cell-Material Sciences, Kyoto Univ.), Tappei Takada (The Univ. of Tokyo Hospital), Atsunori Oshima (Cellular and Structural Physiology Inst., Nagoya Univ.), Keiichi Inoue (Nagoya Inst. of Technology)
Outline: Membrane transporters play essential roles in maintaining life and expression of cell-specific functions. Hence, functions of membrane transporters are attractive issue from beginning of life science and are described in many textbooks. For instance, Gap junctions in the freeze-fracture electron microscopy, cystinuria as a transporter deficiency, alternating-access model of transport and bacteriorhodpsin are documented in textbooks for biochemistry. However, studies of membrane transporters at those ages were still in the primitive stage and contained many errors and remained questions. Recent progress of biochemical and biophysical studies are solving these questions.In this symposium, we will introduce up-to-date studies of membrane transporters illustrated in the old textbooks.
3S15
Date: September 27 9:00-11:30 Place: Room 15 (B204, Lecture Rooms B, Kawauchi Campus)
New development of thiol biology
Organizers: Hideshi Ihara (Osaka Pref. Univ.), Tomohiro Sawa (Kumamoto Univ.)
Speakers / Outline: ▼
Speakers: Hideshi Ihara (Osaka Pref. Univ.), Tomohiro Sawa (Kumamoto Univ.), Takahiro Shibata (Nagoya Univ.), Hidemitsu Nakajima (Osaka Pref. Univ.), Yasuo Watanabe (Showa Pharmaceutical Univ.), Takafumi Suzuki (Tohoku Univ.)
Outline: Thiol moieties (-SH) in low molecular substances such as glutathione and cysteine and in proteins play essential roles in diverse biochemical processes including regulation of redox cellular signaling and oxidative stress responses. In addition to oxidation-dependent disulfide formation (-SS-), recent advances in understanding of thiol biology have clarified importance of newly identified unique chemical modifications of thiols via nitrosylation (-SNO) and sulfhydration (-SSH) in physiological as well as pathological aspects. This symposium will provide a forum for exchanging paradigm shifting knowledge on thiol biology, and discuss future perspectives towards understanding of next generation thiol biology.
3S16
Date: September 27 9:00-11:30 Place: Room 16 (B101, Lecture Rooms B, Kawauchi Campus)
Circadian clock as an interface of the environmental stress responses and internal variation
Organizers: Kazuhiro Yagita (Kyoto Pref. Univ. of Medicine), Yoshitaka Fukada (The Univ. of Tokyo)
Speakers / Outline: ▼
Speakers: Kazuhiro Yagita (Kyoto Pref. Univ. of Medicine), Shuji Nakanishi (Res. Ctr. for Solar Energy Chemistry, Osaka Univ.), Hiromi Shimojo (Inst. for Virus Research, Kyoto Univ.), Yoshikado Sanada (Isotope Science Center, The Univ. of Tokyo), Qing Jun Meng (Univ. Manchester, UK), Wataru Nakamura (Osaka Univ.), Kimiko Shimizu (The Univ. of Tokyo)
Outline: The circadian clock cycles with a period of approximately 24 hours and regulates various physiological phenomena such as sleep-wake cycle, hormone rhythms and energy metabolism in mammals. Light-dark cycle and many other environmental time cues regulate the oscillation speed and the phase of the circadian clock, leading to synchronization of the internal clock with the dynamic change in environmental parameters. On the other hand, environmental stress such as disturbance of light-dark schedule causes dysfunction of circadian clocks and causes a wide spectrum of diseases including cancer risks. It is now important to explore the mechanism underlying these changes. In this symposium we propose challenging approaches to these issues.
3S17
Date: September 27 9:00-11:30 Place: Room 17 (B102, Lecture Rooms B, Kawauchi Campus)
Multiple RNA control freak CCR4-NOT protein complex revealing novel paradigm of gene expression.
Organizers: Keiji Kuba (Akita Univ.), Yukako Chiba (Hokkaido Univ.)
Speakers / Outline: ▼
Speakers: Tadashi Yamamoto (OIST), Toshinobu Fujiwara (Kinki Univ.), Yuichiro Mishima (Inst. of Molecular and Cellular Bioscience, The Univ. of Tokyo), Martine Collart (Univ. of Geneva Medical School), Joseph Reese (Pennsylvania State Univ.), Yukako Chiba (Hokkaido Univ.), Keiji Kuba (Akita Univ.)
Outline: The CCR4-NOT protein complex was originally identified as a regulator of transcription in yeasts and was then shown to have RNA decay factor, and is now recognized to have multiple roles in controlling gene expression. While mechanisms of transcription and translation had been extensively studied, which mostly ended up with their own, it has recently been revealed that each process of gene expressions are interconnected and regulated by certain proteins. The RNA decay subunit of CCR4-NOT is reported to regulate transcriptional activity. Thus, a new concept to describe gene expression as a circular system has been launched and attracted the field. In this symposium, we overview multiple functions of CCR4-NOT in diverse species and discuss new aspects of RNA regulation and gene expression.
3S18
Date: September 27 9:00-11:30 Place: Room 18 (B103, Lecture Rooms B, Kawauchi Campus)
Lessons in gene expression system from yeast
Organizers: Mitsuhiro Shimizu (Meisei Univ.), Yukio Mukai (Nagahama Inst. of Bio-Science and Technology)
Speakers / Outline: ▼
Speakers: Mitsuhiro Shimizu (Meisei Univ.), Hiroaki Kato (Shimane Univ.), Junichi Nakayama (Nagoya City Univ.), Masahiko Harata (Tohoku Univ.), Katsunori Tanaka (Kwansei Gakuin Univ.), Masaya Oki (Univ. of Fukui), Yuka Kamei (Nagahama Inst. of Bio-Science and Technology)
Outline: Since the yeast cell shares common structural and functional features with other eukaryotic cells, discoveries in yeast have established many landmarks in molecular and cellular biology. By utilizing the advantages of yeast, such as its applicability in biochemistry, molecular biology, genome wide analysis and genetics, studies in yeast have contributed in leading ways to the fields. In this symposium, we have invited a variety of speakers who study gene expression system. The speakers will present their unique research on the mechanisms of transcriptional regulation, chromatin structure and function, epigenetics and aging. These results, as lessons from yeast, will be discussed toward understanding fundamental mechanisms in higher eukaryotes.
3S19
Date: September 27 9:00-11:30 Place: Room 19 (B104, Lecture Rooms B, Kawauchi Campus)
Frontline of exosome biology: Closing up functions of glyco-related molecules
Organizers: Chihiro Sato (Nagoya Univ.), Yoichiro Harada (Kagoshima Univ.)
Speakers / Outline: ▼
Speakers: Chihiro Sato (Nagoya Univ.), Yoichiro Harada (Kagoshima Univ.), Kenzi Oshima (Nagoya Univ.), Tatsuyuki Yamashita (Kochi Medical School), Naomi Ohnishi (Japanese Foundation for Cancer Research), Ayuko Hoshino (Weill Medical College of Cornell Univ., USA)
Outline: Exosomes secreted from many types of cells mediate local and distant intercellular communications. While nucleic acids are well-characterized signal transducers in the exosomes, glycans and their modifying enzymes on the exosomal surface also serve as a frontline of exosomal functions in various cellular processes. The aim of this symposium is to promote integrative understanding of exosome biology that would develop new medical applications by introducing glycobiology, together with other multidisciplinary studies, on the biomodulatory functions of the exosomal glyco-related molecules. Six up-and-coming researchers on cancer, immunity, neuron, fertilization and mammary gland, will provide their up-to-date topics on exosome-glycobiology and the perspectives of new frontiers.
Forum
List of Forum
| No. | Date | Place | Session Theme |
|---|---|---|---|
| 1F05 | September 25 | Room 5 (Sakura 2, Conference bldg., Sendai International Center) | Biochemistry for sustainable global health |
| 1F08 | September 25 | Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center) | Interplay between peptide functional design and biochemistry: control of molecular interaction and the biological responces |
| 1F09 | September 25 | Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center) | Understanding membrane morphology by computational, chemical, and cell biological analysis of membrane-binding proteins. |
| 1F10 | September 25 | Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center) | Current and future advances in biomaterials and artificial organs |
| 2F05 | September 26 | Room 5 (Sakura 2, Conference bldg., Sendai International Center) | Recent findings regarding the diverse physiological functions executing by the sulfur atom and its containing biomolecules |
| 2F08 | September 26 | Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center) | Novel biochemistry created by designer peptides and proteins |
| 2F09 | September 26 | Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center) | City or Local. How we choose the research environment in the future? |
| 2F10 | September 26 | Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center) | Can we find the trace of the origin and early evolution of the life system in the current biochemical reactions? |
| 3F05 | September 27 | Room 5 (Sakura 2, Conference bldg., Sendai International Center) | Age-associated disease and superoxide dismutase (SOD) |
| 3F08 | September 27 | Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center) | New Vistas of Biochemistry Revealed by Superresolution Microscopy |
| 3F09 | September 27 | Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center) | New Trends in Structural Biology: 15th Anniversary of PDBj and future perspectives |
| 3F10 | September 27 | Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center) | In vivo crystallization - Understanding of cellular response to intracellular environmental change and application - |
Outline
<How to read the session numbers>
Date+ Abbreviation+ Room
Ex.) 1F02: The 1st day/Forum/Room 2
Day 1 (September 25)
1F05
Date: 13:30-15:30 Place: Room 5 (Sakura 2, Conference bldg., Sendai International Center)
Biochemistry for sustainable global health
Organizers: Kiyoshi Kita (The Univ. of Tokyo), Takafumi Tsuboi (Proteo-Science Center, Ehime Univ.)
Speakers / Outline: ▼
Speakers: Shigeharu Harada (Kyoto Inst. of Technology), Takafumi Tsuboi (Proteo-Science Center, Ehime Univ.), Satoshi Kaneko (Inst. of Tropical Medicine, Nagasaki Univ.), Shinji Fukuda (Inst. for Advanced Biosciences, Keio Univ.), Ayato Takada (Res. Center for Zoonosis Control, Hokkaido Univ.)
Outline: Infectious diseases are one of the most serious issues in the world when we consider "global health" as we know Ebola from 2013 to 2015 in Western Africa. More than 3 million deaths annually in developing countries. Although the drugs such as chloroquine and artesunate are the common treatment against malaria, but there is the emergence and spread of resistant strains. To improve this situation, diagnosis, treatment and prevention are essential. Nobel prize in 2015 for drug development of parasitic diseases means a hope of the people in the world. This symposium is focusing on the role of biochemical approach to combat against the infectious diseases. Current progress of "Diagnosis, Drug discovery and vaccine development" will be presented and discussed.
1F08
Date: 13:30-15:30 Place: Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center)
Interplay between peptide functional design and biochemistry: control of molecular interaction and the biological responces
Organizers: Shiroh Futaki (Inst. for Chemical Res., Kyoto Univ.), Kazuyasu Sakaguchi (Hokkaido Univ.)
Speakers / Outline: ▼
Speakers: Ayami Matsushima (Kyushu Univ.), Yoshiro Chuman (Niigata Univ.), Miki Imanishi (Kyoto Univ.), Motoyoshi Nomizu (Tokyo Univ. of Pharmacy and Life Sciences), Ikuhiko Nakase (Osaka Pref. Univ.), Youhei Sohma (The Univ. of Tokyo /JST-ERATO), Yuki Goto (The Univ. of Tokyo), Masahito Yoshida (Tohoku Univ.), Rui Kamada (Hokkaido Univ.)
Outline: The recent development in biochemistry and the related fields has been elucidating protein molecular interplays in our life. Functional design of peptides to modulate these interplays has also gained considerable development. Peptides can be designed based on protein structural motifs where non-coding amino acids and various chemical modifications are also employable. There was a significant development in the methodologies in peptide synthesis in the past decades, which provides novel means in controlling biological interplays. The aim of this symposium is to cultivate novel research areas in biochemistry through the discussions on the topics about recent progress in peptide synthesis, functional design, and the applications to the modulation of biological interactions.
1F09
Date: 13:30-15:30 Place: Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center)
Understanding membrane morphology by computational, chemical, and cell biological analysis of membrane-binding proteins.
Organizers: Shiro Suetsugu (Nara Inst. of Science and Technology), Akio Kitao (Inst. of Molecular and Cellular Bioscience, the Univ. of Tokyo)
Speakers / Outline: ▼
Speakers: Kazuya Tsujita (Kobe Univ.), Kazuma Yasuhara (Nara Inst. of Science and Technology), Hiroshi Noguchi (ISSP, The Univ. of Tokyo), Masashi Tachikawa (RIKEN), Shiro Suetsugu (Nara Inst. of Science and Technology)
Outline: Lipid membrane is an essential component of the most of the cellular organelles. The shape of lipid membrane, i.e., the shape of organelles, is thought to be scalped by lipid-binding proteins, which include BAR domain proteins and so on. In this process, the shape of the membrane is determined by the super-molecular assemblies of these lipid-binding proteins, however, it is still largely unclear how the assemblies of lipid-binding proteins are regulated, suggesting that the approaches other than biochemistry would be necessary. In this symposium, various researchers in various disciplines will give talks on membrane morphology.
1F10
Date: 13:30-15:30 Place: Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center)
Current and future advances in biomaterials and artificial organs
Organizers: Hisanori Horiuchi (Tohoku Univ.), Koichi Kokame (National Cerebral and Cardiovascular Center)
Speakers / Outline: ▼
Speakers: Hisanori Horiuchi (IDAC, Tohoku Univ.), Kouetsu Ogasawara (IDAC, Tohoku Univ.), Tetsuji Yamaoka (National Cerebral and Cardiovascular Center Research Inst.), Osamu Suzuki (Tohoku Univ.), Toshiya Fujisato (Osaka Inst. of Technology), Yuuki Inoue (The Univ. of Tokyo)
Outline: Artificial organs have remarkably been developed, where metals and polymers that are absent in our body are used. They sometimes induce abnormal reactions in immunological and hemostasis systems. Meanwhile, regenerative medicine that utilizes biomaterials have also exhibited rapid progression, some of which are used in clinical settings. Here, we will discuss current situations and future directions of artificial biomaterials and organs from the side of biochemistry on following issues: 1) bleeding disorder, acquired von Willebrand syndrome, caused by high shear stress in artificial hearts, 2) metal allergy, 3) scaffolds using biomaterials for tissue regeneration, 4) bone and muscle regeneration using artificial materials, and 5) binding of proteins and cells on the interface of polymers.
Day 2 (September 26)
2F05
Date: 13:30-15:30 Place: Room 5 (Sakura 2, Conference bldg., Sendai International Center)
Recent findings regarding the diverse physiological functions executing by the sulfur atom and its containing biomolecules
Organizers: Yoichi Sakakibara (Univ. of Miyazaki), Kei Wada (Org. for Promotion of Tenure Track, Univ. of Miyazaki)
Speakers / Outline: ▼
Speakers: Yoichi Sakakibara (Univ. of Miyazaki), Akiko Maruyama (Kyushu Univ.), Yoshimitsu Kakuta (Kyushu Univ.), Shigemoto Fujii (Tohoku Univ.), Kei Wada (Organization for Promotion of Tenure Track,Univ. of Miyazaki)
Outline: Sulfur belongs to the same group in the periodic table as oxygen, but the two elements manifest distinctly different properties. The orbital electrons of sulfur atom are said to be more flexible than those of oxygen and thus bring a higher reactivity for sulfur as an essential element for all living cells. In biomolecules, sulfur atom is found not only in glutathione and the activated sulfate, but also in cofactors of proteins such as biotin and iron-sulfur clusters etc. This symposium will cover a range of topics concerning the recent findings about sulfur atom and sulfur-containing biomolecules from the viewpoint of inorganic chemistry, biochemistry, molecular biology, as well as structural biology.
2F08
Date: 13:30-15:30 Place: Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center)
Novel biochemistry created by designer peptides and proteins
Organizers: Masahiro Kawahara (The Univ. of Tokyo), Hiroyuki Imanaka (Okayama Univ.)
Speakers / Outline: ▼
Speakers: Masahiro Kawahara (The Univ. of Tokyo), Hiroyuki Imanaka (Okayama Univ.), Takaaki Kojima (Nagoya Univ.), Tomoaki Matsuura (Osaka Univ.), Mitsuo Umetsu (Tohoku Univ.), Tomoko Yoshino (Tokyo Univ. of Agriculture and Technology), Kei Kanie (Nagoya Univ.)
Outline: The progress of biochemistry has accumulated our knowledge on functional peptides and proteins within cells. Meanwhile, biochemists are paying attention to studies in which novel techniques for biochemical analyses are developed by designing functional peptides and proteins based on such knowledge, which may be applied to drug discovery and medicine. Recent progress is prominent in developing both in vitro and in vivo platforms for selecting functional peptides/proteins from a library. These platforms allow us to perform a wide range of research subjects from basics to applications. This symposium aims to introduce cutting-edge studies of young researchers who are energetically conducting studies on designer peptides and proteins, and to discuss novel biochemistry created by this field.
2F09
Date: 13:30-15:30 Place: Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center)
City or Local. How we choose the research environment in the future?
Organizers: Yoshiyuki Matsubara (Nagoya Univ.), Ryosuke Nishimura (Tohoku Univ.)
Speakers / Outline: ▼
Speakers:
Outline: Recently, we often hear “a disparity of the research environment between a city and a rural area”. When young researchers belonging to urban universities and local universities meet each other, the regional differences, such as the access to transportation, the amount of information and neighboring research facilities, become popular topics of conversation. Furthermore, deals pushing the globalization of urban universities were established; on the other hand, local universities were recommended the contribution to the local revitalization. It is expected that the directionality of the university will be definitely polarized between urban and local universities. How should young researchers choose the research environment from now on?
2F10
Date: 13:30-15:30 Place: Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center)
Can we find the trace of the origin and early evolution of the life system in the current biochemical reactions?
Organizers: Gota Kawai (Chiba Inst. of Technology), Yoshitaka Bessho (Academia Sinicia)
Speakers / Outline: ▼
Speakers: Gota Kawai (Chiba Inst. of Technology), Yoshitaka Bessho (Academia Sinica, Taiwan), Tairo Oshima (Kyowa Kako Co., Ltd.), Makoto Nishiyama (Biotechnology Research Center, The Univ. of Tokyo), Toshio Iwasaki (Nippon Medical Sch.), Ai Muto (Nara Inst. of Science and Technology)
Outline: Most of the basic biochemical pathways and reactions have been analyzed in the twenty century、 and structures of many enzymes working in the major pathways were solved during the last two decades. Now we can discuss the biological reaction mechanisms based on the protein structures、 and evaluate the relationship between the current biochemical pathways/reactions and the origin/evolution of primary and potentially primordial biomaterials. In this symposium、 we will survey the trace of the origin and early evolution of the life system in the current biochemical reactions、 in the light of the accumulated results in biochemical and structural analyses.
Day 3 (September 27)
3F05
Date: 14:25-16:25 Place: Room 5 (Sakura 2, Conference bldg., Sendai International Center)
Age-associated disease and superoxide dismutase (SOD)
Organizers: Akihito Ishigami (Tokyo Metro. Inst. of Gerontology), Takahiko Shimizu (Chiba Univ.)
Speakers / Outline: ▼
Speakers: Takahiko Shimizu (Chiba Univ.), Tetsuro Kamiya (Gifu Pharmaceutical Univ.), Dogru Murato (Keio Univ.), Yoshitaka Kondo (Tokyo Metro. Inst. of Gerontology)
Outline: Superoxide dismutase (SOD) is an antioxidant enzyme that converts superoxide anion radicals into hydrogen peroxide and molecular oxygen. In mammals, SOD consists of three isozymes: SOD1 (Cu, Zn-SOD), SOD2 (Mn-SOD), SOD3 (EC-SOD). Gene deletion or mutations of SOD causes various pathological conditions with an impact on the life. For example, SOD1-knockout (KO) mice showed age-related macular degeneration, retinal degeneration, skin atrophy, osteoporosis, deterioration of Alzheimer's disease, and luteal and lacrimal degeneration. In this symposium, we introduce the latest knowledge in the top runners of SOD study about the impact of abnormality of redox balance due to the loss of the SOD.
3F08
Date: 14:25-16:25 Place: Room 8 (Meeting Room 2, Exhibition bldg., Sendai International Center)
New Vistas of Biochemistry Revealed by Superresolution Microscopy
Organizers: Michihiro Igarashi (Niigata Univ.), Yasuki Ishizaki (Gunma Univ.)
Speakers / Outline: ▼
Speakers: Motohiro Nozumi (Niigata Univ.), Kiichi Fukui (Osaka Univ.), Tomomi Nemoto (Res.h Inst. for Electronic Science, Hokkaido Univ. ), Hitoshi Tatsumi (Kanazawa Inst. of Technology), Shigeyuki Namiki (The Univ. of Tokyo), Testsuya Takahashi (Hiroshima Univ.)
Outline: Biochemistry in the near future is to understand where and what the focused molecule perform the interactions, and how the cellular functions are induced to change by the interactional shifts in a given intracellular site. To achieve this purpose, the most powerful technique has been innovated, i.e., superresolution microscopy. In Japan, in spite of the importance of the biochemical analysis at superresolution level, there were not so many studies using superresolution. Through the talks of the revolutionary new results using superresolution microscopy (SIM, STED, or PALM), we will discuss the next age of imaging which leads to the new vistas of cellular biochemistry.
3F09
Date: 14:25-16:25 Place: Room 9 (Meeting Room 3, Exhibition bldg., Sendai International Center)
New Trends in Structural Biology: 15th Anniversary of PDBj and future perspectives
Organizers: Kei Yura (Ochanomizu Univ.), Kengo Kinoshita (Tohoku Univ.)
Speakers / Outline: ▼
Speakers: Haruki Nakamura (Osaka Univ.), Kei Yura (Ochanomizu U), Kenji Iwasaki (Osaka Univ.), Kenji Sugase (Kyoto Univ.), Toru Ekimoto (Yokohama City Univ.)
Outline: This is the 15th anniversary of PDBj and the last year of PDIS project, both of which have strongly supported the activity of structural biology. Structural biology being a standard and powerful approach for the deeper understand of biochemical phenomena, it is worth celebrating the anniversary of PDBj, reconsidering the role of structural biology and discussing its future perspectives and impact on biochemistry. In this session, we put aside the historical stories of the field, and we aim to introduce and discuss the new trends of structural biology techniques that will bring fruitful new insights about the biochemical studies. The new techniques will include a hybrid approach of electron microscopy and X-ray crystallography for the better understanding of biochemical phenomenon on the supramolecular complexes at atomic resolution level, and combined approach of experimental and computational methods such as MD-SAX to grasp large structural changes in the suparmolecules.
3F10
Date: 14:25-16:25 Place: Room 10 (Meeting Room 4, Exhibition bldg., Sendai International Center)
In vivo crystallization - Understanding of cellular response to intracellular environmental change and application -
Organizers: Kohji Itoh (Tokushima Univ.), Fumiaki Yumoto (KEK/High Energy Accelerator Research Organization)
Speakers / Outline: ▼
Speakers: Leonard Chavas (Synchrotron Soleil, France), Haruki Hasegawa (Amgen, USA), Hidekazu Tsutsui (Japan Advanced Inst. of Science and Technology), Fumiaki Yumoto (Inst. of Materials Structure Science, KEK), Kohji Itoh (Tokushima Univ.)
Outline: In recent years in vivo crystallization of several proteins has been
demonstrated in different organisms and cultured cell lines. The intracellular localization of in vivo protein crystals and the mechanisms behind crystallizations such as intracellular responses against crystals should be different. For instance, a fluorescent protein was crystallized in cytoplasm. However, the crystals were also observed in autophagosomes. Moreover, overexpressed glycoproteins, which are usually transported in vesicles, were crystallized in rough ER. In this symposium, recent discoveries in the field will be introduced. In addition, challenges toward elucidation of the three dimensional structures with diffraction method will be discussed.
Talks (Oral Presentation from Poster) & Posters
The schedule and titles of the presentations are available on the ”Program search / Abstract browsing system” in the website or ”Program search / Abstract browsing Application”.
[NOTE]
Free papers accepted as oral presentation as well will be presented as both poster and oral presentations.
Therefore, those papers have both oral presentation and poster presentation numbers.
e.g.:”2T01-01（2P-123）”
Oral Presentation number “2T01-01” represents: Day2, Room 1, 1st presenter
Poster Presentation number “2P-123” represents: Day2, Panel No. 123
Late-breaking Abstracts
The papers submitted as Late-breaking Abstracts are available on the “Program search / Abstract browsing system” on the website or “Program search / Abstract browsing App”. (They are not included in the printed Program booklets.)
The programs can be accessed by anyone, however, you need a password to browse the abstracts.
You can use this password for both “Program search / Abstract browsing system” and “Program search / Abstract browsing App”
ID and password to log in My Page are printed in the meeting badge.
For nonmembers who wish to purchase Program booklet and to access Program search / browsing system, please contact JBS Secretariat.
Japanese Biochemical Society secretariat
TEL +81(0)3-3815-1913 E-mail: jbs-ho@jbsoc.or.jp
Bio-industry Seminars
Access Program search / Abstract browsing system or use Program search / Abstract browsing App for detail information of Bio-industry Seminars or speakers.
